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Mir-764 microRNA precursor family : ウィキペディア英語版 | Mir-764 microRNA precursor family
In molecular biology mir-764 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. ==Osteoblast Differentiation== Expression of the mature miR-764-5p sequence is upregulated during osteoblast differentiation in both skull-specific calvarial and osteoblast progenitor cells. The channel-forming integral protein, CHIP, is regulated by miR-764-5p at its 3'UTR, and there is negative correlation between expression of the two. Increased CHIP levels are observed with inhibition of miR-764-5p, whilst enhanced miR-764-3p expression sees decreased CHIP levels. The differentiation fate of osteoblast progenitor cells is altered by impaired miR-764-3p levels due to CHIP. Osteoblast differentiation from progenitor cells has been shown to be positively regulated by repressed CHIP translation.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Mir-764 microRNA precursor family」の詳細全文を読む
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